Assuming similar high affinity sulfonylurea binding sites in human hearts, the signal transduction between the occupied sulfonylurea receptor and the channel pore seems to be different in human cardiac myocytes when compared to mouse pancreatic B-cells. (Quelle: bmb+f Forschungslandkarte Deutschland 1998)
Animal heart cells have high affinity sulfonylurea receptors and a good correlation has been observed between the affinities for the different sulfonylureas in heart cells and in pancreatic B-cells (Fosset et al. 1988). (Quelle: bmb+f Forschungslandkarte Deutschland 1998)
By comparison, glibenclamide blocks KATP channels from pancreatic B-cells in the nanomolar concentration range and this high affinity is at least partially explained by the slow dissociation of glibenclamide from the receptor (Zünkler et al. 1988a). (Quelle: bmb+f Forschungslandkarte Deutschland 1998)
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